Echinoidea (Sea Urchin)
The Immune Receptors in the sea urchin are cytoplasmic pattern recognition receptors recognize
a variety of microbial signatures, including LPS, peptidoglycan, dsRNA and flagellin.62
Structurally, NLRs are composed of C‑terminal LRRs, a central NACHT domain and
one of several N‑terminal domains that function in protein‑protein interactions. NLRs in
mammals function in the immune response by serving as scaffolding proteins to assemble
protein complexes that lead to the activation of the NFkB and MAPK signalling pathways.
a variety of microbial signatures, including LPS, peptidoglycan, dsRNA and flagellin.62
Structurally, NLRs are composed of C‑terminal LRRs, a central NACHT domain and
one of several N‑terminal domains that function in protein‑protein interactions. NLRs in
mammals function in the immune response by serving as scaffolding proteins to assemble
protein complexes that lead to the activation of the NFkB and MAPK signalling pathways.